CALL FOR PAPERS Cardiovascular Aging Ovariectomy is protective against renal injury in the high-salt-fed older mRen2.Lewis rat
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s, A591, 2007. 40. Zha Y, Le VT, Higami Y, Shimokawa I, Taguchi T, Razzaque MS. Life-long suppression of growth hormone-insulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage. Endocrinology 147: 5690–5698, 2006. 41. Zicha J, Kunes J. Ontogenetic aspects of hypertension development: analysis in the rat. Physiol Res 79: 1227–1282, 1999. 42. Zwaka TP, Hombach V, Torzewski J. C-reactive protein-mediated low density lipoprotein uptake by macrophages. Implications for atherosclerosis. Circulation 103: 1194–1197, 2001.H2071OVARIECTOMY IN OLDER mRen2.LEWIS RATS AJP-Heart Circ Physiol • VOL 293 • OCTOBER 2007 • www.ajpheart.orgby10.0.33.3onJne5,2017http://ajphphysiology.org/Downladedfom
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Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat.
Studies in experimental animals and younger women suggest a protective role for estrogen; however, clinical trials may not substantiate this effect in older females. Therefore, the present study assessed the outcome of ovariectomy in older mRen2. Lewis rats subjected to a high-salt diet for 4 wk. Intact or ovariectomized (OVX, 15 wk of age) mRen2. Lewis rats were aged to 60 wk and then placed o...
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The influence of estrogen on the regulation of cardiovascular function remains a controversial and complex area of investigation. We assessed the effects of estrogen depletion in the congenic mRen(2). Lewis rat, established from the back-cross of the original (mRen2)-27 transgenic onto the Lewis inbred strain. Ovariectomy of heterozygous mRen(2). Lewis at 4 to 5 weeks resulted in a progressive ...
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INTRODUCTION The G protein-coupled estrogen receptor (GPER) is expressed in various tissues including the heart. Since the mRen2.Lewis strain exhibits salt-dependent hypertension and early diastolic dysfunction, we assessed the effects of the GPER agonist (G-1, 40 nmol/kg/hr for 14 days) or vehicle (VEH, DMSO/EtOH) on cardiac function and structure. METHODS Intact female mRen2.Lewis rats were...
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IT IS WELL ESTABLISHED THAT cardiovascular disease is a leading cause of death in developed countries, but it is less well known that more women than men die of cardiovascular disease, although these deaths are delayed by 10 yr (7, 17). It is becoming evident that there is considerable sexual dimorphism in the pathogenesis of cardiovascular disease. Thus findings from past studies, mostly in ma...
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Objective(s): Repaglinide (RG) is an antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. It has a good safety and efficacy profile in diabetic patients with complications in renal impairment and is an appropriate treatment choice, even for individuals with more severe degrees of renal malfunctions. The aim of the present study was to examine the protective...
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